Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 19/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.59 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22121187 | 0.90 | STING1 (0.64) | STING1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL22121578 | 0.89 | STING1 (0.69) | STING1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL19449009 | 0.88 | STING1 (1.00) | STING1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29619909 | 0.88 | STING1 (1.00) | STING1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL22119062 | 0.86 | STING1 (0.69) | STING1TBK1 | |
| SCHEMBL29868363 | 0.85 | STING1 (1.00) | STING1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL22121383 | 0.85 | STING1 (0.66) | STING1TBK1 | |
| SCHEMBL22121271 | 0.85 | STING1 (0.59) | STING1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL22121551 | 0.85 | STING1 (0.68) | STING1TBK1 | |
| SCHEMBL22121136 | 0.85 | STING1 (0.67) | STING1CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132566-A1 | STING PYRAZOLE AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020132582-A1 | STING AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |