Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | STING1 | Q86WV6 | 6/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | IRF3 | Q14653 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22119002 | 0.85 | HTT (0.47) | HTTSTING1BRD4KEAP1NFE2L2 | |
| SCHEMBL1201709 | 0.79 | ALDH1A1 (0.47) | HTTSMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL22118998 | 0.79 | STING1 (0.53) | STING1IRF3 | |
| SCHEMBL22118965 | 0.78 | TLR8 (0.41) | HTTSTING1BRD4KEAP1NFE2L2 | |
| SCHEMBL4881757 | 0.77 | STING1 (0.44) | STING1LMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL22119105 | 0.76 | STING1 (0.53) | HTTSTING1 | |
| SCHEMBL29784473 | 0.76 | MAPT (0.42) | STING1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL22118988 | 0.75 | STING1 (0.66) | STING1IRF3 | |
| SCHEMBL8505526 | 0.74 | HTT (0.52) | HTTKEAP1NFE2L2LMNASMN1; SMN2 | |
| SCHEMBL22118961 | 0.74 | STING1 (0.45) | HTTSTING1BRD4KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132566-A1 | STING PYRAZOLE AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |