Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 8/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30171757 | 1.00 | TTK (0.44) | TTKMAPKAPK5TGFBR1KDM4EGAA | |
| SCHEMBL30183184 | 0.92 | TTK (0.46) | TTKMAPKAPK5KDM4EGAASMN1; SMN2 | |
| SCHEMBL22142812 | 0.90 | TTK (0.43) | TTKMAPKAPK5KDM4EGAASMN1; SMN2 | |
| SCHEMBL22123500 | 0.90 | MAPKAPK5 (0.49) | TTKMAPKAPK5CD274MAPTTSHR | |
| SCHEMBL22123797 | 0.90 | PTK6 (0.45) | TTKMAPKAPK5PTK6CD274EGFR | |
| SCHEMBL22122944 | 0.88 | PTK6 (0.47) | TTKMAPKAPK5PTK6CD274 | |
| SCHEMBL30349788 | 0.87 | TTK (0.47) | TTKMAPKAPK5PTK6SYK | |
| SCHEMBL22124768 | 0.87 | TTK (0.47) | TTKMAPKAPK5PTK6SYK | |
| SCHEMBL22124775 | 0.86 | PTK6 (0.45) | TTKMAPKAPK5PTK6CD274EGFR | |
| SCHEMBL22124457 | 0.86 | TTK (0.42) | TTKMAPKAPK5KDM4EGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898631-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | claimed |
| WO-2020126953-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | claimed |