Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123059 | 0.89 | PTK6 (0.39) | KDM4EGAASMN1; SMN2PTK6MAPKAPK5 | |
| SCHEMBL22125051 | 0.89 | PTK6 (0.39) | KDM4EGAASMN1; SMN2PTK6MAPKAPK5 | |
| SCHEMBL30349820 | 0.89 | PTK6 (0.39) | KDM4EGAASMN1; SMN2PTK6MAPKAPK5 | |
| SCHEMBL24112523 | 0.89 | PTK6 (0.41) | KDM4EGAASMN1; SMN2PTK6MET | |
| Hydrochloric Acid SCHEMBL25176396 | 0.89 | PTK6 (0.39) | KDM4EGAASMN1; SMN2PTK6MAPKAPK5 | |
| SCHEMBL25450711 | 0.88 | PTK6 (0.38) | KDM4EGAASMN1; SMN2PTK6MAPKAPK5 | |
| SCHEMBL22123746 | 0.87 | KDR (0.38) | KDM4EGAASMN1; SMN2PTK6KDR | |
| SCHEMBL30171724 | 0.87 | KDR (0.38) | KDM4EGAASMN1; SMN2PTK6KDR | |
| SCHEMBL22123564 | 0.86 | MCHR1 (0.41) | KDM4EGAAKDRSMYD2CHRNA7 | |
| SCHEMBL24940112 | 0.86 | PTK6 (0.39) | PTK6MAPKAPK5TTKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898631-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | claimed |
| WO-2020126953-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | claimed |
| US-20230012368-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-12 | — | — | US | disclosed |
| US-20230012368-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230012368-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | MRPL21, MYD88, IL1R1 | KDM4E 3688/4885GAA 1417/4885SMN1; SMN2 1986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.