Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 5/20 | 0.43 |
| ▸ | TTK | P33981 | 8/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30187378 | 1.00 | PTK6 (0.43) | PTK6TTKMAPKAPK5AURKBSYK | |
| SCHEMBL22142748 | 0.89 | PTK6 (0.45) | PTK6TTKMAPKAPK5AURKBSYK | |
| SCHEMBL30187306 | 0.89 | PTK6 (0.45) | PTK6TTKMAPKAPK5AURKBSYK | |
| SCHEMBL22123157 | 0.88 | TTK (0.44) | PTK6TTKMAPKAPK5AURKBSYK | |
| SCHEMBL30171704 | 0.88 | TTK (0.44) | PTK6TTKMAPKAPK5AURKBSYK | |
| SCHEMBL24870951 | 0.84 | TTK (0.45) | PTK6TTKMAPKAPK5AURKBSYK | |
| SCHEMBL30171585 | 0.84 | TTK (0.45) | PTK6TTKMAPKAPK5AURKBSYK | |
| SCHEMBL22139064 | 0.84 | MAPKAPK5 (0.46) | PTK6TTKMAPKAPK5AURKBSYK | |
| SCHEMBL22123361 | 0.84 | MAPKAPK5 (0.44) | PTK6TTKMAPKAPK5AURKBSYK | |
| SCHEMBL22124929 | 0.84 | PTK6 (0.48) | PTK6TTKMAPKAPK5AURKBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230013602-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-19 | — | — | US | disclosed |
| EP-3898629-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020127075-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230013602-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | IL4, RPS4Y1, RPS4X | PTK6 1818/4885TTK 4519/4885MAPKAPK5 516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.