IL4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL23833502	1.00	1/20
SCHEMBL23833503	1.00	1/20
SCHEMBL31695332	0.78	1/20
SCHEMBL3371543	0.77	1/20
SCHEMBL23841221	0.77	1/20
SCHEMBL29331857	0.77	1/20
SCHEMBL31139632	0.76	1/20
SCHEMBL31139657	0.74	1/20
SCHEMBL31695325	0.72	1/20
SCHEMBL31695349	0.72	1/20
SCHEMBL31695312	0.71	1/20
SCHEMBL22215854	0.70	1/20
SCHEMBL6251702	0.68	1/20
SCHEMBL6251291	0.66	1/20
SCHEMBL23841119	0.66	1/20
SCHEMBL31695327	0.66	1/20
SCHEMBL31139650	0.65	1/20
SCHEMBL23841107	0.65	1/20
SCHEMBL31695362	0.64	1/20
SCHEMBL31695303	0.64	1/20

Clinical trials — most relevant to IL4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Sublingual Immunotherapy in Patients With Atopic Dermatitis	PHASE4	COMPLETED
Impact of Vitamin A on Multiple Sclerosis (MS)	PHASE4	UNKNOWN
A Study of Lebrikizumab in Combination With Topical Corticosteroids in Patients With Atopic Dermatitis (AD) That Are Not Adequately Controlled With or Are Non-eligible for Cyclosporine	PHASE3	COMPLETED
Observation on the Efficacy and Mechanism of SLIT With Dust Mite Allergen for PAR	PHASE2/PHASE3	UNKNOWN
Effects of Allopurinol on Inflammation and Ultrasonographic Changes in People With Elevated Uric Acid But no Symptoms	PHASE3	UNKNOWN
Investigation of Efficacy and Safety of Ragweed MATAMPL, Pollinex-R and Placebo in Patients With Ragweed Allergy	PHASE2	COMPLETED
Recombinant Human IL-4 Receptor Used in Treatment of Asthma	PHASE2	COMPLETED
Intranasal Inhalations of Bioactive Factors Produced by M2 Macrophages in Patients With Organic Brain Syndrome	PHASE1/PHASE2	COMPLETED
T Cell Effector and Regulatory Mechanisms in Asthma	PHASE1	COMPLETED
Q702 for the Treatment of Patients With Hematologic Malignancies	PHASE1	RECRUITING
Impact of Comorbidities, Some Biomarkers, Micro RNA in Childhood Asthma Phenotypes	nan	NOT_YET_RECRUITING
Interleukin-34 in Stage I and II Periodontitis	nan	COMPLETED
Blood Lymphocytes in Asthmatics Treated With Therapeutic Proteins	nan	COMPLETED
Comparison of the Human Papillomavirus (HPV) Type 16 E7-Specific Immune Response Between a Normal Population and Patients With Cervical Lesions	nan	UNKNOWN
T Cell Cytokine Changes During IL-4 Receptor Treatment for Asthma	nan	COMPLETED
To Assess the Management of Patients on Global Initiative of Asthma (GINA) Step 4 and 5 Treatment in Hong Kong	nan	RECRUITING
Interleukin 4 and Interferon Gamma Predictors of Human Papillomavirus Immunotherapy in Warts	nan	COMPLETED
Interleukin-4 in Pityriasis Lichenoides Chronica	nan	NOT_YET_RECRUITING
Cocarnit Effects on Macrophages Polarization	nan	COMPLETED
Effect of Different Therapeutic Strategies on Regulatory T Cells in Kidney Transplantation	nan	COMPLETED
Microbiome and Immune Profiling in Infant With Cow's Milk Allergy	nan	UNKNOWN
Effect of SARS-CoV-2 Disease on Immune Responses, Disease Severity and Treatment Outcomes in Pulmonary Tuberculosis	nan	UNKNOWN
The Development of Human Papillomavirus Type 16 E7-Specific Human Immunologic Assays in Non-HLA2 Type Human Being	nan	UNKNOWN
Glioma Microenvironment an Exploratory Study	nan	ACTIVE_NOT_RECRUITING
Immune Dysregulation in Children and Adults With Asthma	nan	COMPLETED
Study on Biomarkers to Predict the Efficacy of IL-4R Monoclonal Antibody for Chronic Rhino-sinusitis With Polyps	nan	UNKNOWN
Translational Study of the Effects of Neural Mobilization in Patients With Lomboisquiatalgia	nan	COMPLETED
Chemerin, Fetuin-A, IL-34 and IL-13 Levels in Diabetic Periodontitis Patients	nan	COMPLETED
Phenotyping Circulating and Lung Resident Eosinophils in Severe Asthma (P-CLESA)	nan	UNKNOWN
Efficacy of Oral Supplementation of Probiotics in Children With Atopic Dermatitis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a IL4 binder may also engage these)

Protein	Name	Similarity
Q8HYB1	—	1.000	Q8HYB1 →
P46652	—	1.000	P46652 →
Q865Y0	—	1.000	Q865Y0 →
P51492	—	1.000	P51492 →
P79339	—	1.000	P79339 →
P79155	—	1.000	P79155 →
P15247	—	0.999	P15247 →
P51744	—	0.998	P51744 →
P47966	—	0.998	P47966 →
P42202	—	0.998	P42202 →
Q6EBC2	—	0.997	Q6EBC2 →
Q08081	—	0.997	Q08081 →
Q3S4V6	—	0.997	Q3S4V6 →
Q9ESI9	—	0.997	Q9ESI9 →
P30367	—	0.997	P30367 →
Q865X5	—	0.997	Q865X5 →
P52173	—	0.997	P52173 →
O97513	—	0.996	O97513 →
Q9XT91	—	0.996	Q9XT91 →
P20096	—	0.996	P20096 →
IL2	Interleukin-2	0.996	landscape →
P07750	—	0.996	P07750 →
Q9JJY9	—	0.996	Q9JJY9 →
Q62575	—	0.996	Q62575 →
Q76LU6	—	0.995	Q76LU6 →
P15248	—	0.995	P15248 →
Q95J68	—	0.995	Q95J68 →
P42203	—	0.995	P42203 →
Q9XS58	—	0.995	Q9XS58 →
Q28586	—	0.995	Q28586 →