Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 15/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.43 |
| ▸ | TTK | P33981 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 5/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30177817 | 1.00 | PTK6 (0.50) | PTK6AURKBTTKLCKMAPKAPK5 | |
| SCHEMBL22124498 | 0.97 | PTK6 (0.53) | PTK6AURKBTTKLCKMAPKAPK5 | |
| SCHEMBL30171606 | 0.97 | PTK6 (0.53) | PTK6AURKBTTKLCKMAPKAPK5 | |
| SCHEMBL22124574 | 0.89 | PTK6 (0.53) | PTK6AURKBTTKLCKMAPKAPK5 | |
| SCHEMBL30177691 | 0.89 | PTK6 (0.53) | PTK6AURKBTTKLCKMAPKAPK5 | |
| SCHEMBL30171983 | 0.88 | PTK6 (0.52) | PTK6AURKBTTKLCKMAPKAPK5 | |
| SCHEMBL22125155 | 0.88 | PTK6 (0.52) | PTK6AURKBTTKLCKMAPKAPK5 | |
| SCHEMBL22142735 | 0.88 | PTK6 (0.50) | PTK6AURKBTTKLCKMAPKAPK5 | |
| SCHEMBL22124013 | 0.88 | PTK6 (0.52) | PTK6AURKBTTKLCKMAPKAPK5 | |
| SCHEMBL22125450 | 0.86 | TTK (0.52) | PTK6AURKBTTKLCKMAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897839-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | claimed |
| WO-2020126952-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | claimed |
| EP-3897839-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020126952-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |