SCHEMBL22130714

SCHEMBL22130714

Nc1ccc(-c2cn(S(=O)(=O)c3ccccc3)c3c2C(=O)C(=O)C=C3)cc1

nearest known ligand 0.83

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ELAVL1 Q15717 7/20 0.83
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA9 Q16790 1/20 0.43
HTR6 P50406 8/20 0.43
MMP2 P08253 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
PKM P14618 1/20 0.36
HPGD P15428 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HTR1A P08908 1/20 0.35
HTR7 P34969 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19737490 0.91 ELAVL1 (1.00) ELAVL1CA12CA1CA2CA9
Dimethylamine SCHEMBL21222569 0.86 ELAVL1 (0.90) ELAVL1CA12CA1CA2CA9
SCHEMBL19737482 0.84 ELAVL1 (0.77) ELAVL1HTR6L3MBTL1MEN1LMNA
SCHEMBL19737562 0.84 ELAVL1 (0.77) ELAVL1CA12CA1CA2CA9
SCHEMBL22130694 0.83 ELAVL1 (0.79) ELAVL1CA12CA1CA2CA9
SCHEMBL21222486 0.82 ELAVL1 (1.00) ELAVL1CA12CA1CA2CA9
SCHEMBL19737425 0.82 ELAVL1 (0.83) ELAVL1CA12CA1CA2CA9
SCHEMBL22130634 0.82 ELAVL1 (0.83) ELAVL1CA12CA1CA2CA9
SCHEMBL22130693 0.81 ELAVL1 (0.81) ELAVL1CA12CA1CA2CA9
SCHEMBL22130675 0.81 ELAVL1 (0.92) ELAVL1HTR6MEN1PKMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10689342-B2 Aza-tanshinone derivatives, process for their preparation and their use in therapy UNIVERSITA' DEGLI STUDI DI TRENTO (IT) 2020-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10689342-B2 Aza-tanshinone derivatives, process for their preparation and their use in therapy AZI2, TPMT, TYMS ELAVL1 2765/4885CA12 3782/4885CA1 3680/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.