SCHEMBL22133449

C=C1C(=O)N[C@@H](C)C(=O)N(C)[C@@H](C)C(=O)N[C@@H]([C@H](OC(=O)[C@@H](NC(=O)CC)[C@H](ONC)C(C)C)C(C)C)C(=O)N(C)[C@@H]([C@@H](C)OC)C(=O)O[C@H](C(C)C)[C@H](NC(C)=O)C(=O)O[C@H](Cc2ccccc2)C(=O)N1C

nearest known ligand 0.87

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	GNA11	P29992	8/20	0.87

▸	GNAQ	P50148	3/20	0.87

▸	ELANE	P08246	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL22139591	0.96	GNA11 (0.90)	GNA11GNAQELANE
SCHEMBL22133467	0.94	GNA11 (0.87)	GNA11GNAQELANE
SCHEMBL22139590	0.94	GNA11 (0.86)	GNA11GNAQELANE
SCHEMBL22116269	0.94	GNA11 (0.86)	GNA11GNAQELANE
SCHEMBL22133481	0.93	GNA11 (0.85)	GNA11GNAQELANE
SCHEMBL22139627	0.93	GNA11 (1.00)	GNA11GNAQELANE
SCHEMBL22404883	0.93	GNA11 (1.00)	GNA11GNAQELANE
SCHEMBL22133450	0.93	GNA11 (1.00)	GNA11GNAQELANE
SCHEMBL22404881	0.93	GNA11 (1.00)	GNA11GNAQELANE
SCHEMBL26121610	0.93	GNA11 (1.00)	GNA11GNAQELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2020128612-A2	ANTIBODIES TO PMEL17 AND CONJUGATES THEREOF	NOVARTIS AG (CH)	2020-06-25	—	—	WO	disclosed