Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 2/20 | 0.49 |
| ▸ | CDC42 | P60953 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 6/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22135858 | 1.00 | CYP2D6 (0.58) | CYP2D6KCNH2DHODHCDC42GAA | |
| SCHEMBL30455919 | 1.00 | CYP2D6 (0.58) | CYP2D6KCNH2DHODHCDC42GAA | |
| SCHEMBL22135733 | 0.88 | CYP2D6 (0.70) | CYP2D6KCNH2DHODHCDC42GAA | |
| SCHEMBL4191954 | 0.88 | CYP2D6 (0.70) | CYP2D6KCNH2DHODHCDC42GAA | |
| SCHEMBL30455081 | 0.88 | CYP2D6 (0.70) | CYP2D6KCNH2DHODHCDC42GAA | |
| Hydrochloric Acid SCHEMBL4160295 | 0.87 | CYP2D6 (0.69) | CYP2D6KCNH2DHODHCDC42GAA | |
| SCHEMBL25247842 | 0.86 | RB1 (0.55) | CDC42BRD3PKMKDM4EALDH1A1 | |
| SCHEMBL4201376 | 0.85 | CYP2D6 (0.65) | CYP2D6KCNH2DHODHCDC42GAA | |
| Hydrochloric Acid SCHEMBL4165595 | 0.84 | CYP2D6 (0.64) | CYP2D6KCNH2DHODHCDC42GAA | |
| SCHEMBL22135775 | 0.84 | CYP2D6 (0.58) | CYP2D6KCNH2DHODHCDC42GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220062233-A1 | Compounds for the Reduction of the Deleterious Activity of Extended Nucleotide Repeat Containing Genes | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2022-03-03 | — | — | US | disclosed |
| WO-2020131573-A1 | COMPOUNDS FOR THE REDUCTION OF THE DELETERIOUS ACTIVITY OF EXTENDED NUCLEOTIDE REPEAT CONTAINING GENES | NUREDIS, INC. (US) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220062233-A1 | Compounds for the Reduction of the Deleterious Activity of Extended Nucleotide Repeat Containing Genes | NSUN2, RTCB, RRM2B | CYP2D6 3475/4885KCNH2 4714/4885DHODH 332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.