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RRM2B

Ribonucleoside-diphosphate reductase subunit · Q7LG56 · RRM2B on Sugi Atlas →

4,106 patent compounds predicted against RRM2B, 2,752 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL3267534 SCHEMBL3267534 0.37 11/20
SCHEMBL12453317 SCHEMBL12453317 0.85 9/20
SCHEMBL9848709 SCHEMBL9848709 0.54 7/20
SCHEMBL6153460 SCHEMBL6153460 0.56 6/20
SCHEMBL12026317 SCHEMBL12026317 0.54 6/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL9148122) 0.50 6/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL9459299) 0.50 6/20
SCHEMBL5181864 SCHEMBL5181864 0.56 5/20
SCHEMBL5181869 SCHEMBL5181869 0.56 5/20
SCHEMBL10688777 SCHEMBL10688777 0.39 5/20
SCHEMBL5181464 SCHEMBL5181464 0.62 4/20
SCHEMBL5181467 SCHEMBL5181467 0.62 4/20
SCHEMBL5182078 SCHEMBL5182078 0.57 4/20
SCHEMBL5182463 SCHEMBL5182463 0.57 4/20
SCHEMBL5180221 SCHEMBL5180221 0.50 4/20
SCHEMBL6843084 SCHEMBL6843084 0.50 4/20
SCHEMBL6665515 SCHEMBL6665515 0.48 4/20
SCHEMBL5179588 SCHEMBL5179588 0.54 3/20
SCHEMBL5179591 SCHEMBL5179591 0.54 3/20
SCHEMBL5181488 SCHEMBL5181488 0.54 3/20

Clinical trials — most relevant to RRM2B by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision PHASE3COMPLETED
S0720: Adjuvant Therapy Based on Gene Expression in Stage IA and IB Non-Small Cell Lung Cancer PHASE2COMPLETED
Mobilization of Stem Cells With G-CSF for Collection From Patients With Diamond-Blackfan Anemia PHASE2COMPLETED
Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome PHASE2RECRUITING
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation PHASE2UNKNOWN
Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Adolescent Subjects With RPS19 Deficient Diamond-Blackfan Anemia PHASE1RECRUITING
Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa PHASE1COMPLETED
DNA Repair Genes and Outcomes in Patients With Stage III NSCLC nanUNKNOWN
Natural History in Primary Mitochondrial Myopathies nanRECRUITING
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing nanRECRUITING
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models nanCOMPLETED
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients nanCOMPLETED
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants nanRECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
Performance of Inherited Risk Assessment for Predicting Prostate Cancer From Prostate Biopsy nanRECRUITING
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
Micro Ribosomal Nucleic Acid 155 in Non Hodgkin Lymphoma nanCOMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
Choroid Plexus Dysfunction in Neurological Diseases nanRECRUITING
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others nanRECRUITING
Repeated Bout Effect i Neuromuscular Diseases nanRECRUITING
Molecular Characterisation of Colorectal Cancer Peritoneal Metastases nanRECRUITING
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
Study of Specimens From Young Patients With Neuroblastoma nanCOMPLETED
InsightRP2 Registry nanRECRUITING
Molecular Genetics of Retinal Degenerations nanCOMPLETED
Genetic Factors Affecting the Severity of Beta Thalassemia nanCOMPLETED
Gene Expression in Patients With Epiretinal Membranes nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a RRM2B binder may also engage these)

ProteinNameSimilarity
Q5R9G0 — 1.000 Q5R9G0 →
Q4R741 — 0.998 Q4R741 →
Q6PEE3 — 0.996 Q6PEE3 →
Q4R7Q7 — 0.980 Q4R7Q7 →
Q4KLN6 — 0.978 Q4KLN6 →
Q60561 — 0.977 Q60561 →
RRM2 Ribonucleoside-diphosphate reductase subunit M2 0.973 landscape →
P11157 — 0.973 P11157 →
P79733 — 0.964 P79733 →
Q9DFS6 — 0.912 Q9DFS6 →
Q9CZX0 — 0.911 Q9CZX0 →
Q5R8T8 — 0.908 Q5R8T8 →
A4IHW6 — 0.907 A4IHW6 →
P48597 — 0.907 P48597 →
Q6PA43 — 0.907 Q6PA43 →
A4FV08 — 0.907 A4FV08 →
P20651 — 0.907 P20651 →
GNPDA1 Glucosamine-6-phosphate deaminase 1 0.905 landscape →
Q9CRC9 — 0.905 Q9CRC9 →
P48592 — 0.905 P48592 →
P48453 — 0.904 P48453 →
Q17QL1 — 0.903 Q17QL1 →
Q3V1L4 — 0.902 Q3V1L4 →
A0A7H0DN21 — 0.902 A0A7H0DN21 →
G1SKZ8 — 0.902 G1SKZ8 →
PPP3CB Serine/threonine protein phosphatase PP2B-alpha catalytic subunit 0.901 landscape →
Q9VQZ6 — 0.901 Q9VQZ6 →
Q8TDQ7 — 0.901 Q8TDQ7 →
O88958 — 0.900 O88958 →
P48454 — 0.900 P48454 →