SCHEMBL22136019

SCHEMBL22136019

Nc1cc(-c2ccccc2)nc2c1ccc1cccnc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.51
TOP1 P11387 5/20 0.51
ADORA2A P29274 2/20 0.48
ADORA1 P30542 2/20 0.48
LMNA P02545 3/20 0.47
KDM4E B2RXH2 3/20 0.47
HSP90AA1 P07900 2/20 0.47
CCR1 P32246 2/20 0.47
CCR5 P51681 2/20 0.47
CCR8 P51685 2/20 0.47
MAPT P10636 2/20 0.47
GMNN O75496 1/20 0.47
TP53 P04637 1/20 0.47
MMP2 P08253 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
MMP9 P14780 1/20 0.47
ALOX15 P16050 1/20 0.47
TSHR P16473 1/20 0.47
NFKB1 P19838 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28659827 0.86 TOP1 (0.59) TOP1LMNAKDM4EHSP90AA1CCR1
SCHEMBL22249955 0.85 TOP1 (0.58) TOP1LMNAKDM4EHSP90AA1CCR1
SCHEMBL29551682 0.85 TOP1 (0.58) TOP1LMNAKDM4EHSP90AA1CCR1
SCHEMBL31096961 0.85 TOP1 (0.58) TOP1LMNAKDM4EHSP90AA1CCR1
SCHEMBL22249546 0.84 TOP1 (0.53) TOP1LMNAKDM4EHSP90AA1CCR1
SCHEMBL29645265 0.84 TOP1 (0.53) TOP1LMNAKDM4EHSP90AA1CCR1
SCHEMBL24514805 0.82 TOP1 (0.51) TOP1LMNAKDM4EHSP90AA1CCR1
SCHEMBL22127729 0.82 TOP1 (0.51) TOP1LMNAKDM4EHSP90AA1CCR1
SCHEMBL22127733 0.82 L3MBTL1 (0.55) TOP1ADORA1LMNAKDM4EHSP90AA1
SCHEMBL23434686 0.81 TOP1 (0.50) TOP1ADORA2AADORA1LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020130553-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME 두산솔루스 주식회사 2020-06-25 WO disclosed