Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
| ▸ | ITK | Q08881 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22135919 | 1.00 | STING1 (0.53) | STING1ALDH1A1LMNAHPGDTDP1 | |
| SCHEMBL22135972 | 0.95 | STING1 (0.55) | STING1ALDH1A1LMNAHPGDTDP1 | |
| SCHEMBL22136234 | 0.95 | STING1 (0.55) | STING1ALDH1A1LMNAHPGDTDP1 | |
| SCHEMBL22135907 | 0.91 | STING1 (0.58) | STING1ALDH1A1LMNAHPGDTDP1 | |
| SCHEMBL22135975 | 0.88 | STING1 (0.61) | STING1ALDH1A1LMNAHPGDTDP1 | |
| SCHEMBL22118178 | 0.78 | STING1 (0.66) | STING1ALDH1A1HPGDMAP3K7SMN1; SMN2 | |
| SCHEMBL22136152 | 0.77 | STING1 (0.65) | STING1ALDH1A1LMNAHPGDMAP3K7 | |
| SCHEMBL22136228 | 0.77 | STING1 (0.55) | STING1ALDH1A1LMNAHPGDTDP1 | |
| SCHEMBL22136232 | 0.77 | STING1 (0.55) | STING1ALDH1A1LMNAHPGDTDP1 | |
| SCHEMBL22136149 | 0.76 | STING1 (0.64) | STING1ALDH1A1HPGDMAP3K7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132549-A1 | STING HETEROCYCLE AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |