Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 8/20 | 0.52 |
| ▸ | JAK1 | P23458 | 8/20 | 0.52 |
| ▸ | TYK2 | P29597 | 8/20 | 0.52 |
| ▸ | JAK3 | P52333 | 8/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.48 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19436506 | 0.86 | JAK2 (0.62) | CXCR4JAK2JAK1TYK2JAK3 | |
| SCHEMBL22135368 | 0.86 | ADORA2A (0.51) | JAK2JAK1TYK2JAK3TLR8 | |
| SCHEMBL19436566 | 0.83 | JAK2 (0.62) | CXCR4JAK2JAK1TYK2JAK3 | |
| SCHEMBL22136264 | 0.77 | STING1 (0.60) | STING1KMT2A | |
| SCHEMBL19436514 | 0.77 | KDM4E (0.56) | CXCR4JAK2JAK1TYK2JAK3 | |
| SCHEMBL22134963 | 0.77 | HPGD (0.62) | TLR8KMT2AFGFR1 | |
| Bromide SCHEMBL23227960 | 0.76 | KDM4E (0.55) | CXCR4JAK2JAK1TYK2JAK3 | |
| SCHEMBL19437484 | 0.76 | JAK2 (0.56) | CXCR4JAK2JAK1TYK2JAK3 | |
| SCHEMBL19436490 | 0.76 | JAK2 (0.55) | CXCR4JAK2JAK1TYK2JAK3 | |
| SCHEMBL19436504 | 0.76 | JAK2 (0.55) | JAK2JAK1TYK2JAK3TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132549-A1 | STING HETEROCYCLE AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |