Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 15/20 | 0.60 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.47 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22136291 | 0.91 | STING1 (0.55) | STING1TBK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL22151647 | 0.86 | STING1 (0.62) | STING1TBK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL22136287 | 0.83 | STING1 (0.65) | STING1TBK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL22136253 | 0.82 | STING1 (0.50) | STING1TBK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL22135276 | 0.82 | STING1 (0.81) | STING1TBK1 | |
| SCHEMBL22136153 | 0.80 | STING1 (0.57) | STING1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL22136258 | 0.80 | STING1 (0.46) | STING1TBK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL22135934 | 0.78 | STING1 (0.53) | STING1TBK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL22136293 | 0.77 | CXCR4 (0.53) | STING1KMT2A | |
| SCHEMBL22135909 | 0.76 | STING1 (0.61) | STING1TBK1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132549-A1 | STING HETEROCYCLE AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |