Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5155015 | 0.92 | BACE1 (0.41) | BACE1NR3C1HPGD | |
| SCHEMBL4512858 | 0.83 | BACE1 (0.55) | BACE1NR3C1KDM4EALDH1A1 | |
| SCHEMBL2020790 | 0.73 | BACE1 (0.52) | BACE1 | |
| SCHEMBL12578837 | 0.72 | BACE1 (0.59) | BACE1 | |
| SCHEMBL2027404 | 0.71 | BACE1 (0.59) | BACE1 | |
| SCHEMBL2027128 | 0.71 | BACE1 (0.59) | BACE1 | |
| SCHEMBL8264847 | 0.69 | BACE1 (0.39) | BACE1 | |
| SCHEMBL5653669 | 0.69 | BACE1 (0.54) | BACE1ALDH1A1 | |
| SCHEMBL5653668 | 0.69 | BACE1 (0.54) | BACE1ALDH1A1 | |
| SCHEMBL4740207 | 0.67 | BACE1 (0.38) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689713-B1 | BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER S DISEASE | MERCK SHARP & DOHME (US) | 2011-07-27 | — | — | EP | disclosed |