Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 13/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2213775 | 0.92 | BACE1 (0.42) | BACE1NR3C1HPGD | |
| SCHEMBL5651659 | 0.82 | BACE1 (0.47) | BACE1HCAR3TAS2R14 | |
| SCHEMBL2020790 | 0.81 | BACE1 (0.52) | BACE1HCAR3 | |
| SCHEMBL2027404 | 0.79 | BACE1 (0.59) | BACE1HCAR3 | |
| SCHEMBL8264847 | 0.77 | BACE1 (0.39) | BACE1HCAR3TAS2R14 | |
| SCHEMBL12578837 | 0.74 | BACE1 (0.59) | BACE1 | |
| SCHEMBL4512858 | 0.74 | BACE1 (0.55) | BACE1NR3C1 | |
| SCHEMBL2025478 | 0.72 | BACE1 (0.58) | BACE1LMNA | |
| SCHEMBL5653669 | 0.72 | BACE1 (0.54) | BACE1 | |
| SCHEMBL5654238 | 0.72 | POLB (0.39) | BACE1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697308-A4 | PHENYLAMIDE AND PYRIDYLAMIDE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER S DISEASE | MERCK & CO INC (US) | 2007-08-22 | — | — | EP | disclosed |
| EP-1697308-A2 | PHENYLAMIDE AND PYRIDYLAMIDE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER S DISEASE | Merck & Co., Inc. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005065195-A2 | PHENYLAMIDE AND PYRIDYLAMIDE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2005-07-21 | — | — | WO | disclosed |