Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 11/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14314758 | 0.98 | HPGD (0.68) | HPGDTSHRPLA2G7ALDH1A1KMT2A | |
| SCHEMBL2377982 | 0.87 | KMT2A (0.59) | HPGDTSHRALDH1A1KMT2APOLB | |
| SCHEMBL21650768 | 0.87 | HPGD (0.52) | HPGDTSHRPLA2G7ALDH1A1KMT2A | |
| SCHEMBL2376730 | 0.86 | HPGD (0.67) | HPGDALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL10126442 | 0.85 | HPGD (0.68) | HPGDTSHRPLA2G7ALDH1A1KMT2A | |
| SCHEMBL15651212 | 0.84 | ALDH1A1 (0.58) | HPGDTSHRALDH1A1KMT2ACNR2 | |
| SCHEMBL12569383 | 0.84 | HPGD (0.73) | HPGDTSHRPLA2G7ALDH1A1KMT2A | |
| SCHEMBL2956998 | 0.84 | HPGD (0.62) | HPGDTSHRALDH1A1KDM4ELRRK2 | |
| SCHEMBL848798 | 0.83 | HPGD (0.77) | HPGDTSHRPLA2G7ALDH1A1KMT2A | |
| SCHEMBL18753364 | 0.83 | AKR1C1 (0.59) | HPGDTSHRPLA2G7ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020131627-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES | ARRAY BIOPHARMA INC. (US) | 2020-06-25 | — | — | WO | disclosed |