SCHEMBL22138808

SCHEMBL22138808

C[C@@H]1C[C@@H](O)CN1C(=O)C(NC(=O)CN)C(C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 6/20 0.40
DPP8 Q6V1X1 6/20 0.40
DPP9 Q86TI2 6/20 0.40
VHL P40337 13/20 0.36
ELOC Q15369 10/20 0.36
ELOB Q15370 10/20 0.36
DPP7 Q9UHL4 1/20 0.35
FAP Q12884 1/20 0.35
PIK3CD O00329 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26725347 0.88 DPP4 (0.36) DPP4DPP8DPP9VHLELOC
SCHEMBL21759977 0.88 VHL (0.38) DPP4DPP8DPP9VHLELOC
SCHEMBL24558588 0.87 DPP4 (0.36) DPP4DPP8DPP9VHLELOC
SCHEMBL24239716 0.86 DPP4 (0.35) DPP4DPP8DPP9VHLELOC
SCHEMBL22138839 0.86 VHL (0.41) DPP4DPP8DPP9VHLELOC
SCHEMBL22959576 0.85 VHL (0.46) DPP4DPP8DPP9VHLELOC
SCHEMBL23651723 0.85 VHL (0.46) DPP4DPP8DPP9VHLELOC
SCHEMBL23183583 0.83 VHL (0.41) DPP4DPP8DPP9VHLELOC
SCHEMBL21554505 0.83 VHL (0.41) DPP4DPP8DPP9VHLELOC
SCHEMBL21554539 0.83 VHL (0.41) DPP4DPP8DPP9VHLELOC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200199247-A1 ANTIBODY CONJUGATES OF IMMUNE-MODULATORY COMPOUNDS AND USES THEREOF SILVERBACK THERAPEUTICS, INC. 2020-06-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200199247-A1 ANTIBODY CONJUGATES OF IMMUNE-MODULATORY COMPOUNDS AND USES THEREOF LTK, TGFBR2, TNIK DPP4 3570/4885DPP8 2878/4885DPP9 1862/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.