Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 14/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.41 |
| ▸ | LCK | P06239 | 5/20 | 0.38 |
| ▸ | TTK | P33981 | 3/20 | 0.37 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22139168 | 1.00 | PTK6 (0.45) | PTK6AURKBLCKTTKMAPKAPK5 | |
| SCHEMBL22139240 | 1.00 | PTK6 (0.45) | PTK6AURKBLCKTTKMAPKAPK5 | |
| SCHEMBL24910344 | 0.94 | PTK6 (0.40) | PTK6AURKBLCKTTKMAPKAPK5 | |
| SCHEMBL24910502 | 0.94 | PTK6 (0.46) | PTK6AURKBLCK | |
| SCHEMBL22154507 | 0.93 | PTK6 (0.54) | PTK6AURKBLCK | |
| SCHEMBL22139081 | 0.93 | PTK6 (0.54) | PTK6AURKBLCK | |
| SCHEMBL30177571 | 0.92 | PTK6 (0.40) | PTK6AURKBLCKTTKMAPKAPK5 | |
| SCHEMBL22154351 | 0.92 | PTK6 (0.40) | PTK6AURKBLCKTTKMAPKAPK5 | |
| SCHEMBL22142955 | 0.92 | PTK6 (0.44) | PTK6AURKBLCKMAPKAPK5PARP1 | |
| SCHEMBL22139096 | 0.92 | PTK6 (0.44) | PTK6AURKBLCKMAPKAPK5PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898630-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-05-10 | — | — | EP | disclosed |
| EP-3898629-B1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |
| WO-2020126956-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020126954-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020127075-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020126952-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |