Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 8/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.38 |
| ▸ | TTK | P33981 | 6/20 | 0.37 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 3/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22139092 | 0.94 | PTK6 (0.45) | PTK6AURKBTTKMAPKAPK5LCK | |
| SCHEMBL22139168 | 0.94 | PTK6 (0.45) | PTK6AURKBTTKMAPKAPK5LCK | |
| SCHEMBL22139240 | 0.94 | PTK6 (0.45) | PTK6AURKBTTKMAPKAPK5LCK | |
| SCHEMBL24940120 | 0.90 | TTK (0.44) | PTK6AURKBTTKMAPKAPK5AXL | |
| SCHEMBL24940104 | 0.89 | TTK (0.42) | PTK6AURKBTTKSYKAXL | |
| SCHEMBL24910582 | 0.89 | PTK6 (0.36) | PTK6AURKBTTKMAPKAPK5SYK | |
| SCHEMBL24910502 | 0.89 | PTK6 (0.46) | PTK6AURKBLCK | |
| SCHEMBL22139081 | 0.88 | PTK6 (0.54) | PTK6AURKBLCK | |
| SCHEMBL22154507 | 0.88 | PTK6 (0.54) | PTK6AURKBLCK | |
| SCHEMBL22139096 | 0.88 | PTK6 (0.44) | PTK6AURKBMAPKAPK5LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898630-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-05-10 | — | — | EP | disclosed |
| EP-3898629-B1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |