Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 3/20 | 0.48 |
| ▸ | SYK | P43405 | 11/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 5/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30172107 | 1.00 | PTK6 (0.48) | PTK6SYKMAPKAPK5CSF1RMAP4K4 | |
| SCHEMBL22123969 | 0.92 | PTK6 (0.48) | PTK6SYKMAPKAPK5AURKBAURKA | |
| SCHEMBL30385303 | 0.92 | PTK6 (0.48) | PTK6SYKMAPKAPK5AURKBAURKA | |
| SCHEMBL30385212 | 0.92 | PTK6 (0.50) | PTK6SYKMAPKAPK5AURKBLCK | |
| SCHEMBL30171749 | 0.91 | SYK (0.49) | PTK6SYKMAPKAPK5CSF1RMAP4K4 | |
| SCHEMBL22125440 | 0.90 | PTK6 (0.59) | PTK6AURKBLCK | |
| SCHEMBL30171569 | 0.90 | PTK6 (0.59) | PTK6AURKBLCK | |
| SCHEMBL24940106 | 0.89 | SYK (0.44) | PTK6SYKMAPKAPK5CSF1RMAP4K4 | |
| Hydrochloric Acid SCHEMBL30349837 | 0.89 | SYK (0.43) | PTK6SYKMAPKAPK5CSF1RMAP4K4 | |
| Trifluoroacetic Acid SCHEMBL30386106 | 0.88 | PTK6 (0.47) | PTK6SYKMAPKAPK5AURKBLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898630-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-05-10 | — | — | EP | disclosed |
| WO-2020126954-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020126952-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |