SCHEMBL22146151

SCHEMBL22146151

c1ccc(-c2nc(-c3ccccc3)nc(-c3ccc(-n4c5ccccc5c5cc(-c6cc7c8c(c6)Oc6ccccc6N8c6ccccc6O7)ccc54)cc3)n2)cc1

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.35
ATM Q13315 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
EDNRA P25101 2/20 0.34
EDNRB P24530 1/20 0.34
PTGER4 P35408 1/20 0.33
RAC2 P15153 1/20 0.33
RAC3 P60763 1/20 0.33
CDC42 P60953 1/20 0.33
RAC1 P63000 1/20 0.33
NPY5R Q15761 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22145869 0.93 EDNRB (0.33) KDM4EATML3MBTL1EDNRAEDNRB
SCHEMBL22145875 0.93 NPY5R (0.31) EDNRAEDNRBNPY5R
SCHEMBL15944568 0.91 KDM4E (0.34) KDM4EATML3MBTL1EDNRAEDNRB
SCHEMBL12333547 0.90 L3MBTL1 (0.44) KDM4EATML3MBTL1EDNRAEDNRB
SCHEMBL19035954 0.90 EDNRB (0.31) KDM4EATML3MBTL1EDNRAEDNRB
SCHEMBL17471210 0.90 KDM4E (0.38) KDM4EATML3MBTL1EDNRAEDNRB
SCHEMBL17278456 0.90 KDM4E (0.38) KDM4EATML3MBTL1EDNRAEDNRB
SCHEMBL17278713 0.90 KDM4E (0.38) KDM4EATML3MBTL1EDNRAEDNRB
SCHEMBL22146059 0.89 EDNRB (0.33) KDM4EATML3MBTL1EDNRAEDNRB
SCHEMBL22145879 0.88 MEN1 (0.34) KDM4EATML3MBTL1EDNRAEDNRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3615542-B1 COMPOUNDS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2023-08-23 EP disclosed
US-11649249-B2 Compounds for electronic devices MERCK PATENT GMBH (DE) 2023-05-16 US disclosed
US-11649249-B2 Compounds for electronic devices MERCK PATENT GMBH (DE) 2023-05-16 US disclosed
US-20200199154-A1 COMPOUNDS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2020-06-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11649249-B2 Compounds for electronic devices DDT, CYP2C9, CYP2D6 KDM4E 2128/4885ATM 2015/4885L3MBTL1 3711/4885
US-20200199154-A1 COMPOUNDS FOR ELECTRONIC DEVICES DDT, CYP2C9, CYP2D6 KDM4E 2128/4885ATM 2015/4885L3MBTL1 3711/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.