Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 5/20 | 0.34 |
| ▸ | KLK1 | P06870 | 5/20 | 0.34 |
| ▸ | KLK6 | Q92876 | 4/20 | 0.34 |
| ▸ | PLAU | P00749 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | HPGD | P15428 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2211370 | 0.91 | LOXL2 (0.34) | NAMPTPLGKLK1KLK6PLAU | |
| SCHEMBL2214178 | 0.91 | KDM4E (0.39) | NAMPTPLGKLK1KLK6PLAU | |
| SCHEMBL2211331 | 0.88 | KDM4E (0.39) | NAMPTPLGKLK1KLK6PLAU | |
| SCHEMBL2215134 | 0.88 | LOXL2 (0.38) | NAMPTPLGKLK1PLAUF2 | |
| SCHEMBL2211719 | 0.88 | LOXL2 (0.35) | NAMPTCDK2MAPTHPGDSMN1; SMN2 | |
| SCHEMBL2253400 | 0.88 | MEN1 (0.35) | NAMPTPLGKLK1KLK6C3AR1 | |
| SCHEMBL2211773 | 0.87 | PLG (0.38) | NAMPTPLGKLK1KLK6MAPT | |
| SCHEMBL2213647 | 0.86 | LOXL2 (0.37) | NAMPTPLGKLK1PLAUF2 | |
| SCHEMBL2215322 | 0.86 | KDM4E (0.37) | NAMPTPLGKLK1PLAUF2 | |
| SCHEMBL2213715 | 0.85 | SMN1; SMN2 (0.38) | PLGKLK1PLAUF2PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797096-B1 | PYRAZOLOPYRIMIDINES AS INHIBITORS OF PROTEIN KINASE B (AKT) | BAYER SCHERING PHARMA AG (DE) | 2011-07-27 | — | — | EP | disclosed |