Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 4/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377043 | 0.97 | MEN1 (0.47) | MEN1KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL303294 | 0.96 | MEN1 (0.47) | MEN1KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL302949 | 0.95 | MEN1 (0.49) | MEN1KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL2214837 | 0.94 | MEN1 (0.44) | MEN1KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL3409723 | 0.85 | MEN1 (0.45) | MEN1KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL2211916 | 0.84 | MEN1 (0.42) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL2215417 | 0.84 | KMT2A (0.37) | MEN1KMT2ANPC1RAB9AHSD17B10 | |
| SCHEMBL303432 | 0.83 | LMNA (0.42) | MEN1KMT2AKDM4EPSEN1PSEN2 | |
| SCHEMBL303633 | 0.83 | MEN1 (0.47) | MEN1KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL2214180 | 0.83 | MEN1 (0.54) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | disclosed |