Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 4/20 | 0.35 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.30 |
| ▸ | DRD2 | P14416 | 3/20 | 0.30 |
| ▸ | DRD3 | P35462 | 3/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | BCR | P11274 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL125213 | 0.84 | CBFB (0.46) | CBFBRUNX1FGFR1ACHEDRD2 | |
| SCHEMBL22147371 | 0.73 | CBFB (0.43) | CBFBRUNX1FGFR1ACHEDRD2 | |
| SCHEMBL126325 | 0.72 | CBFB (0.52) | CBFBRUNX1FGFR1DRD2DRD3 | |
| SCHEMBL19997143 | 0.71 | CBFB (0.35) | CBFBRUNX1FGFR1ACHEDRD2 | |
| SCHEMBL179150 | 0.67 | CBFB (0.56) | CBFBRUNX1FGFR1 | |
| SCHEMBL179145 | 0.67 | CBFB (0.56) | CBFBRUNX1FGFR1 | |
| SCHEMBL12944362 | 0.67 | CBFB (0.44) | CBFBFGFR1 | |
| SCHEMBL125214 | 0.67 | CBFB (0.53) | CBFBRUNX1 | |
| SCHEMBL125273 | 0.67 | KCNH2 (0.45) | CBFBFGFR1 | |
| SCHEMBL125204 | 0.67 | CBFB (0.54) | CBFBRUNX1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3670509-A1 | INHIBITORS OF INV(16) LEUKEMIA | The University of Virginia Patent Foundation (US) | 2020-06-24 | — | — | EP | disclosed |