Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 3/20 | 0.43 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL125213 | 0.86 | CBFB (0.46) | CBFBRUNX1FGFR1DRD2DRD3 | |
| SCHEMBL126325 | 0.76 | CBFB (0.52) | CBFBRUNX1FGFR1DRD2DRD3 | |
| SCHEMBL22147402 | 0.76 | CBFB (0.53) | CBFBRUNX1FGFR1MAPTKMT2A | |
| SCHEMBL19997143 | 0.75 | CBFB (0.35) | CBFBRUNX1FGFR1DRD2DRD3 | |
| SCHEMBL22147376 | 0.73 | CBFB (0.35) | CBFBRUNX1FGFR1DRD2DRD3 | |
| SCHEMBL179145 | 0.73 | CBFB (0.56) | CBFBRUNX1FGFR1MAPTKMT2A | |
| SCHEMBL179150 | 0.73 | CBFB (0.56) | CBFBRUNX1FGFR1MAPTKMT2A | |
| SCHEMBL179144 | 0.73 | CBFB (0.56) | CBFBRUNX1FGFR1MAPTKMT2A | |
| SCHEMBL15780000 | 0.72 | CBFB (0.53) | CBFBRUNX1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL179112 | 0.71 | CBFB (0.62) | CBFBRUNX1KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3670509-A1 | INHIBITORS OF INV(16) LEUKEMIA | The University of Virginia Patent Foundation (US) | 2020-06-24 | — | — | EP | disclosed |