Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 4/20 | 0.53 |
| ▸ | RUNX1 | Q01196 | 3/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 8/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL179150 | 0.85 | CBFB (0.56) | CBFBRUNX1FGFR1NPC1RAB9A | |
| SCHEMBL179144 | 0.85 | CBFB (0.56) | CBFBRUNX1FGFR1NPC1RAB9A | |
| SCHEMBL179145 | 0.85 | CBFB (0.56) | CBFBRUNX1FGFR1NPC1RAB9A | |
| SCHEMBL125204 | 0.85 | CBFB (0.54) | CBFBRUNX1PDE3BPDE3AP2RY12 | |
| SCHEMBL15780000 | 0.84 | CBFB (0.53) | CBFBRUNX1PDE3BPDE3AP2RY12 | |
| SCHEMBL125214 | 0.82 | CBFB (0.53) | CBFBRUNX1PDE3BPDE3AP2RY12 | |
| SCHEMBL15780005 | 0.82 | CBFB (0.51) | CBFBRUNX1PDE3BPDE3AP2RY12 | |
| SCHEMBL125224 | 0.82 | CBFB (0.51) | CBFBRUNX1APPACHE | |
| SCHEMBL19831263 | 0.82 | CBFB (0.70) | CBFBRUNX1 | |
| SCHEMBL19831268 | 0.82 | CBFB (0.70) | CBFBRUNX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3670509-A1 | INHIBITORS OF INV(16) LEUKEMIA | The University of Virginia Patent Foundation (US) | 2020-06-24 | — | — | EP | disclosed |