Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL22126580 | 0.88 | NPC1 (0.46) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6289416 | 0.87 | NPC1 (0.55) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL18825755 | 0.87 | NPC1 (0.70) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22147584 | 0.86 | NPC1 (0.56) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9678739 | 0.77 | NPC1 (0.47) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22983218 | 0.77 | RXFP1 (0.64) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL19492504 | 0.77 | KDM4E (0.56) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3615280 | 0.76 | NPC1 (0.49) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2802194 | 0.75 | KDM4E (0.55) | NPC1RAB9AKMT2ASMN1; SMN2TP53 | |
| SCHEMBL31278243 | 0.74 | NPC1 (0.46) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110612302-B | Pyrazolo [1,5-a ] pyrimidine derivatives as kinase JAK inhibitors | 赛隆制药股份公司 | 2022-06-14 | — | — | CN | disclosed |
| US-11072619-B2 | Pyrazole[1,5-a] pyrimidine derivatives as kinase JAK inhibitors | CELON PHARMA S.A. (PL) | 2021-07-27 | — | — | US | disclosed |
| EP-3621966-B1 | PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES AS KINASE JAK INHIBITORS | Celon Pharma Sa (PL) | 2020-11-18 | — | — | EP | disclosed |
| US-20200199128-A1 | PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES AS KINASE JAK INHIBITORS | CELON PHARMA S.A. (PL) | 2020-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11072619-B2 | Pyrazole[1,5-a] pyrimidine derivatives as kinase JAK inhibitors | JAK1, JAK3, JAK2 | NPC1 2526/4885RAB9A 2334/4885KMT2A 1955/4885 |
| US-20200199128-A1 | PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES AS KINASE JAK INHIBITORS | JAK1, JAK3, JAK2 | NPC1 2526/4885RAB9A 2334/4885KMT2A 1955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.