SCHEMBL22148239

SCHEMBL22148239

Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC2)CC3)nc(N2CC3CC3C2)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22262221 1.00 KIF18A (1.00) KIF18A
SCHEMBL22148244 1.00 KIF18A (1.00) KIF18A
SCHEMBL22281886 1.00 KIF18A (1.00) KIF18A
SCHEMBL29371086 1.00 KIF18A (1.00) KIF18A
SCHEMBL29370369 0.97 KIF18A (1.00) KIF18A
SCHEMBL22262197 0.97 KIF18A (1.00) KIF18A
SCHEMBL29370315 0.93 KIF18A (1.00) KIF18A
SCHEMBL22148452 0.93 KIF18A (1.00) KIF18A
SCHEMBL22148238 0.93 KIF18A (1.00) KIF18A
SCHEMBL29370844 0.93 KIF18A (1.00) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020132648-A1 KIF18A INHIBITORS AMGEN INC. (US) 2020-06-25 — — WO disclosed
Send feedback