Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | IDH1 | O75874 | 4/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4597831 | 0.83 | DRD2 (0.52) | DRD2DRD3GRIN1GRIN2BHDAC1 | |
| SCHEMBL5051400 | 0.75 | PLAU (0.55) | DRD2DRD3GRIN1GRIN2B | |
| SCHEMBL8267166 | 0.75 | DRD2 (0.55) | DRD2DRD3GRIN1GRIN2BHDAC1 | |
| SCHEMBL29668981 | 0.75 | PLAU (0.55) | DRD2DRD3GRIN1GRIN2B | |
| SCHEMBL12891735 | 0.75 | DRD2 (0.55) | DRD2DRD3GRIN1GRIN2BHDAC1 | |
| SCHEMBL14819902 | 0.75 | DRD2 (0.51) | DRD2DRD3GRIN1GRIN2BHDAC1 | |
| SCHEMBL1266027 | 0.75 | PLAU (0.55) | DRD2DRD3GRIN1GRIN2B | |
| SCHEMBL22791667 | 0.75 | DRD2 (0.51) | DRD2DRD3GRIN1GRIN2BHDAC1 | |
| SCHEMBL12891728 | 0.75 | DRD2 (0.55) | DRD2DRD3GRIN1GRIN2BHDAC1 | |
| SCHEMBL16595227 | 0.71 | DRD2 (0.41) | DRD2DRD3GRIN1GRIN2BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132661-A2 | INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN | Praxis Biotech LLC (US) | 2020-06-25 | — | — | WO | disclosed |