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SCHEMBL22149352

SCHEMBL22149352

COc1cc(Nc2ccc3ncc(-c4c(C)nn(C5CCN(C(=O)C6(F)CN(C(=O)/C=C/CN(C)C)C6)CC5)c4C)nc3c2)cc(OC)c1

nearest known ligand 0.39

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 14/20 0.39
▸ FGFR2 P21802 13/20 0.39
▸ FGFR3 P22607 11/20 0.39
▸ FGFR4 P22455 10/20 0.39
▸ KDR P35968 4/20 0.39
▸ BTK Q06187 1/20 0.37
▸ BLK P51451 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31655617 1.00 FGFR1 (0.39) FGFR1FGFR2FGFR3FGFR4KDR
SCHEMBL31655626 0.90 FGFR3 (0.41) FGFR1FGFR2FGFR3FGFR4KDR
SCHEMBL22149123 0.90 FGFR3 (0.41) FGFR1FGFR2FGFR3FGFR4KDR
SCHEMBL22149354 0.88 FGFR3 (0.40) FGFR1FGFR2FGFR3FGFR4KDR
SCHEMBL31655635 0.88 FGFR3 (0.40) FGFR1FGFR2FGFR3FGFR4KDR
SCHEMBL22149199 0.85 FGFR3 (0.49) FGFR1FGFR2FGFR3FGFR4KDR
SCHEMBL31655657 0.85 FGFR3 (0.49) FGFR1FGFR2FGFR3FGFR4KDR
SCHEMBL31655643 0.83 FGFR3 (0.48) FGFR1FGFR2FGFR3FGFR4KDR
SCHEMBL22149196 0.82 FGFR3 (0.39) FGFR1FGFR2FGFR3FGFR4KDR
SCHEMBL31655637 0.82 FGFR3 (0.39) FGFR1FGFR2FGFR3FGFR4KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020131674-A1 7-((3,5-DIMETHOXYPHENYL)AMINO)QUINOXALINE DERIVATIVES AS FGFR INHIBITORS FOR TREATING CANCER ARRAY BIOPHARMA INC. (US) 2020-06-25 — — WO disclosed