Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.68 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.48 |
| ▸ | CLK2 | P49760 | 6/20 | 0.48 |
| ▸ | CLK3 | P49761 | 6/20 | 0.48 |
| ▸ | WNT1 | P04628 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | TOP1 | P11387 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1561257 | 0.83 | CHEK1 (0.61) | CHEK1ACHEDYRK1ACLK2CLK3 | |
| SCHEMBL29475851 | 0.77 | CHUK (0.63) | CHEK1ACHEDYRK1ACLK2CLK3 | |
| SCHEMBL473671 | 0.77 | CHUK (0.63) | CHEK1ACHEDYRK1ACLK2CLK3 | |
| SCHEMBL31485825 | 0.77 | CHUK (0.63) | CHEK1ACHEDYRK1ACLK2CLK3 | |
| SCHEMBL12666705 | 0.77 | MAPT (0.64) | CHEK1ACHEDYRK1ACLK2CLK3 | |
| SCHEMBL27972258 | 0.76 | CHUK (0.63) | CHEK1TDO2KDM4EGABRPGABRD | |
| SCHEMBL1560506 | 0.76 | PIM1 (0.64) | CHEK1ACHEDYRK1ACLK2CLK3 | |
| SCHEMBL1561356 | 0.76 | CHEK1 (0.66) | CHEK1ACHEDYRK1ACLK2CLK3 | |
| SCHEMBL17563213 | 0.73 | CHEK1 (0.53) | CHEK1GSK3BTDO2KDM4EGABRP | |
| SCHEMBL16456187 | 0.72 | CLK3 (0.60) | CHEK1DYRK1ACLK2CLK3WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178053-A1 | AZACARBOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | US | claimed |
| US-20110178053-A1 | AZACARBOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178053-A1 | AZACARBOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME | AOC3, CBR3, IDH3B | CHEK1 786/4885ACHE 4362/4885DYRK1A 3029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.