Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 5/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL383428 | 0.89 | PIM1 (0.60) | CDC7ABL1EGFRSRCKDM4E | |
| SCHEMBL383364 | 0.82 | PIM1 (0.62) | CDC7ABL1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3328360 | 0.80 | PIM1 (0.61) | CDC7KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL383423 | 0.78 | PIM1 (0.59) | CDC7KDM4EALDH1A1PIM1CSNK2A2 | |
| SCHEMBL12514652 | 0.78 | PIM1 (0.58) | CDC7KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL385382 | 0.78 | PIM1 (0.58) | CDC7ABL1SRCKDM4EHSD17B10 | |
| SCHEMBL383834 | 0.76 | PIM1 (0.56) | CDC7KDM4EHSD17B10ALDH1A1PIM1 | |
| SCHEMBL385759 | 0.76 | PIM1 (0.61) | CDC7KDM4EALDH1A1PIM1CSNK2A2 | |
| SCHEMBL4758874 | 0.76 | CDC7 (0.63) | CDC7KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL385521 | 0.75 | PIM1 (0.60) | CDC7PIM1CSNK2A2CLK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948617-B1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS INC (US) | 2011-07-27 | — | — | EP | disclosed |