Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 7/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | CTSV | O60911 | 4/20 | 0.45 |
| ▸ | CTSL | P07711 | 4/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28642378 | 1.00 | BCL2 (0.47) | BCL2MCL1CTSVCTSLATM | |
| SCHEMBL22120986 | 0.93 | BCL2 (0.47) | BCL2MCL1ATMPPARAPPARG | |
| SCHEMBL29919587 | 0.83 | BCL2 (0.47) | BCL2MCL1CTSVCTSLATM | |
| SCHEMBL28639840 | 0.82 | CTSV (0.48) | CTSVCTSLPDCD1CD274 | |
| SCHEMBL22154560 | 0.82 | CTSV (0.48) | CTSVCTSLPDCD1CD274 | |
| SCHEMBL22154553 | 0.81 | BCL2 (0.41) | BCL2MCL1CTSVCTSLATM | |
| SCHEMBL31232684 | 0.81 | BCL2 (0.41) | BCL2MCL1CTSVCTSLATM | |
| SCHEMBL29162420 | 0.80 | ACE (0.54) | BCL2MCL1CTSLPPARAPPARG | |
| SCHEMBL22154815 | 0.79 | ATM (0.67) | CTSLATMPPARAPPARGSYK | |
| SCHEMBL22154817 | 0.79 | ATM (0.67) | CTSLATMPPARAPPARGSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118027137-A | Tubulysin and protein-tubulysin conjugates | 里珍纳龙药品有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-113454097-A | Tubulysins and protein-tubulysin conjugates | 里珍纳龙药品有限公司 | 2021-09-28 | — | — | CN | disclosed |
| WO-2020132658-A2 | TUBULYSINS AND PROTEIN-TUBULYSIN CONJUGATES | REGENERON PHARMACEUTICALS, INC. (US) | 2020-06-25 | — | — | WO | disclosed |