Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 12/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | B3GNT2 | Q9NY97 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2975327 | 0.80 | POLB (0.62) | PGRPOLBMAOBB3GNT2DAO | |
| SCHEMBL17807767 | 0.80 | MAOB (0.68) | PGRPOLBMAOBB3GNT2 | |
| SCHEMBL29414802 | 0.79 | PGR (0.60) | PGRPOLBMAOBB3GNT2 | |
| SCHEMBL20987129 | 0.79 | PGR (0.60) | PGRPOLBMAOBB3GNT2 | |
| SCHEMBL29464129 | 0.79 | PGR (0.78) | PGRPOLBMAOBB3GNT2DAO | |
| SCHEMBL2970468 | 0.79 | PGR (0.78) | PGRPOLBMAOBB3GNT2DAO | |
| SCHEMBL2968866 | 0.79 | PGR (0.72) | PGRPOLBMAOBB3GNT2MAPT | |
| SCHEMBL21839392 | 0.76 | PGR (0.57) | PGRPOLBMAOBB3GNT2 | |
| SCHEMBL22152166 | 0.76 | PGR (0.57) | PGRPOLBMAOBB3GNT2 | |
| SCHEMBL30930127 | 0.76 | MAOB (0.64) | PGRPOLBMAOBB3GNT2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200197391-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | Revolution Medicines, Inc. | 2020-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200197391-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | KRAS, NRAS, HRAS | PGR 2823/4885POLB 2323/4885MAOB 3601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.