Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.42 |
| ▸ | BUB1 | O43683 | 1/20 | 0.42 |
| ▸ | PRKACG | P22612 | 1/20 | 0.42 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.42 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2213705 | 0.89 | MAPK14 (0.52) | MAPK14MAPK11CYP2C9CYP3A4 | |
| SCHEMBL2214411 | 0.87 | MAPK14 (0.46) | MAPK14MAPK11CYP2C9CYP3A4 | |
| SCHEMBL2215786 | 0.86 | CYP3A4 (0.51) | MAPK14MAPK11CYP2C9CYP3A4 | |
| SCHEMBL2214347 | 0.86 | MAPK14 (0.52) | MAPK14MAPK11 | |
| SCHEMBL2216452 | 0.86 | MAPK14 (0.51) | MAPK14MAPK11CYP2C9CYP3A4 | |
| SCHEMBL2216809 | 0.85 | CYP3A4 (0.52) | MAPK14MAPK11CYP2C9CYP3A4 | |
| SCHEMBL2215591 | 0.85 | MAPK14 (0.48) | MAPK14MAPK11CYP2C9CYP3A4 | |
| SCHEMBL1416972 | 0.85 | MAPK14 (0.57) | MAPK14MAPK11CYP2C9MAPKAPK2BUB1 | |
| SCHEMBL2216554 | 0.85 | MAPK14 (0.47) | MAPK14MAPK11 | |
| SCHEMBL2216609 | 0.85 | MAPK14 (0.46) | MAPK14MAPK11CYP2C9CYP3A4SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641764-B1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-07-27 | — | — | EP | claimed |