Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214347 | 0.91 | MAPK14 (0.52) | MAPK14MAPK11 | |
| SCHEMBL2218498 | 0.88 | MAPK14 (0.46) | MAPK14MAPK11DRD4 | |
| SCHEMBL2218419 | 0.87 | EPHX2 (0.43) | MAPK14MAPK11TP53EPHX2 | |
| SCHEMBL2213705 | 0.87 | MAPK14 (0.52) | MAPK14MAPK11KIT | |
| SCHEMBL1417370 | 0.86 | MAPK14 (0.59) | MAPK14MAPK11DRD4LMNATP53 | |
| SCHEMBL2215688 | 0.86 | MAPK14 (0.48) | MAPK14MAPK11LMNALCKKIT | |
| SCHEMBL2217376 | 0.85 | MAPK14 (0.45) | MAPK14MAPK11DRD4LMNA | |
| SCHEMBL2215757 | 0.85 | MAPK14 (0.46) | MAPK14MAPK11 | |
| SCHEMBL2214420 | 0.85 | MAPK14 (0.56) | MAPK14MAPK11DRD4 | |
| SCHEMBL2214745 | 0.85 | MAPK14 (0.44) | MAPK14MAPK11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641764-B1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-07-27 | — | — | EP | claimed |