SCHEMBL22158395

SCHEMBL22158395

Cc1ccc(-c2ccc3c4ccccc4n(-c4cc(-c5cc(F)cc(F)c5)cc(-n5c6ccccc6c6ccc(-c7ccc(C)cc7C)cc65)c4C#N)c3c2)c(C)c1

nearest known ligand 0.34

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PDE9A O76083 2/20 0.34
PDE1C Q14123 1/20 0.34
LMNA P02545 1/20 0.32
TP53 P04637 1/20 0.32
HIF1A Q16665 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
KDM4E B2RXH2 1/20 0.31
HPGD P15428 1/20 0.31
PPARG P37231 1/20 0.31
NCOA2 Q15596 1/20 0.31
NCOA1 Q15788 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
NCOA3 Q9Y6Q9 1/20 0.31
PGR P06401 1/20 0.31
GRIN1 Q05586 1/20 0.30
GRIN2B Q13224 1/20 0.30
SQOR Q9Y6N5 1/20 0.30
AR P10275 1/20 0.30
THRB P10828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22158399 0.95 BIRC5 (0.31) PDE9AKDM4E
SCHEMBL22158397 0.94 PDE9A (0.34) PDE9APDE1CLMNATP53HIF1A
SCHEMBL22155903 0.91 AR (0.39) PDE9APDE1CLMNAKDM4EHPGD
SCHEMBL22156717 0.89 PDE9A (0.37) PDE9APDE1CLMNATP53HIF1A
SCHEMBL22158430 0.89 PDE9A (0.38) PDE9APDE1CLMNATP53HIF1A
SCHEMBL21414175 0.89 PDE9A (0.35) PDE9APDE1CLMNATP53HIF1A
SCHEMBL22156732 0.88 PDE1C (0.39) PDE9APDE1CLMNATP53HIF1A
SCHEMBL22157013 0.88 PDE9A (0.39) PDE9APDE1CLMNATP53HIF1A
SCHEMBL22157004 0.88 NR3C1 (0.38) PDE9APDE1CKDM4EHPGDPPARG
SCHEMBL19909221 0.88 PDE9A (0.34) PDE9APDE1CLMNATP53HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200203628-A1 ORGANIC MOLECULES FOR USE IN ORGANIC OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2020-06-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200203628-A1 ORGANIC MOLECULES FOR USE IN ORGANIC OPTOELECTRONIC DEVICES OR10J3, ORC3, OR51E2 PDE9A 4546/4885PDE1C 4637/4885LMNA 4216/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.