Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOL1 | O14791 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Inaxaplin SCHEMBL22118438 | 1.00 | APOL1 (1.00) | APOL1 | |
| Inaxaplin SCHEMBL22118376 | 1.00 | APOL1 (1.00) | APOL1 | |
| Inaxaplin SCHEMBL31006383 | 1.00 | APOL1 (1.00) | APOL1 | |
| Inaxaplin SCHEMBL30218294 | 1.00 | APOL1 (1.00) | APOL1 | |
| Inaxaplin SCHEMBL30008904 | 1.00 | APOL1 (1.00) | APOL1 | |
| Inaxaplin SCHEMBL22118436 | 1.00 | APOL1 (1.00) | APOL1 | |
| Inaxaplin SCHEMBL22118384 | 1.00 | APOL1 (1.00) | APOL1 | |
| SCHEMBL22160137 | 0.94 | APOL1 (0.89) | APOL1 | |
| SCHEMBL22160042 | 0.94 | APOL1 (0.88) | APOL1 | |
| SCHEMBL22160056 | 0.94 | APOL1 (0.88) | APOL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020131807-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-06-25 | — | — | WO | disclosed |