APOL1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL22118316	1.00	20/20
SCHEMBL22118344	1.00	20/20
Inaxaplin (SCHEMBL22118376)	1.00	20/20
Inaxaplin (SCHEMBL22118384)	1.00	20/20
SCHEMBL22118385	1.00	20/20
SCHEMBL22118433	1.00	20/20
Inaxaplin (SCHEMBL22118436)	1.00	20/20
Inaxaplin (SCHEMBL22118438)	1.00	20/20
SCHEMBL22118479	1.00	20/20
SCHEMBL22160054	1.00	20/20
SCHEMBL22160064	1.00	20/20
SCHEMBL22160157	1.00	20/20
SCHEMBL22160158	1.00	20/20
SCHEMBL22160166	1.00	20/20
SCHEMBL22160167	1.00	20/20
SCHEMBL22160197	1.00	20/20
SCHEMBL22160199	1.00	20/20
SCHEMBL22160216	1.00	20/20
SCHEMBL22160301	1.00	20/20
SCHEMBL22161047	1.00	20/20

Clinical trials — most relevant to APOL1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Empagliflozin on Podocyte Specific Proteins in African American Veterans With NDKD	PHASE4	RECRUITING
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS-APO(a)Rx in Participants With High Lipoprotein(a)	PHASE2	COMPLETED
APOL1 Genotyping CTA Clinical Performance Study	nan	RECRUITING
Chronic Kidney Disease : Role of Biological Factors and Apolipoprotein L1 Encoding Gene (APOL1)	nan	COMPLETED
APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)	nan	ACTIVE_NOT_RECRUITING
Genetic Testing to Understand and Address Renal Disease Disparities Across the United States	nan	COMPLETED
Predictive Determinants of Nephrotic Syndrome Remission in Patients With At-risk Polymorphism of APOL1	nan	NOT_YET_RECRUITING
Genetic Testing to Understand and Address Renal Disease Disparities Across the United States Pharmacogenetic Substudy	nan	COMPLETED
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
APOL1 Genetic Testing in African Americans	nan	RECRUITING
Prospective Assessment of Atherosclerotic Cardiovascular Disease (ASCVD) Risk	nan	UNKNOWN
Mechanisms of Low Levels of Apolipoprotein B	nan	COMPLETED
Genetic Testing to Understand and Address Renal Disease Disparities	nan	COMPLETED
Apolipoprotein A-I Gene Polymorphism and Atherosclerosis	nan	COMPLETED
Duke APOL1 Research Biorepository	nan	RECRUITING
The Predictive Capacity of Machine Learning Models for Progressive Kidney Disease in Individuals With Sickle Cell Anemia	nan	UNKNOWN
Evaluation of APOL1 Gene Variants in Kidney Donors and Their Impact on Long-term Renal Function in Donors and Recipients	nan	UNKNOWN
The Effect of Lipoprotein (a) on Arterial Stiffness, Endothelial Function and Myocardial Deformation	nan	RECRUITING
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)	nan	COMPLETED
Apolipoprotein Polymorphisms and Risk of Coronary Heart Disease	nan	COMPLETED
HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism	nan	ACTIVE_NOT_RECRUITING
Kinetic Study of Lp(a) and PCSK9 in Humans	nan	COMPLETED
Advanced Lipoproptein Profiling and Cardiovascular Risk Stratification in Familial Hypercholesterolemia	nan	UNKNOWN
HDL Function Dietary Supplement Safety and QOL	nan	UNKNOWN
VLDL and LDL Particle Types as Coronary Heart Disease Risk Factors	nan	COMPLETED
Studies of Apolipoprotein Genotyping on the Drug Treatment of Hyperlipidemic Patients	nan	COMPLETED
Multi-Analyte, Genetic, and Thrombogenic Markers of Atherosclerosis	nan	UNKNOWN
Hyperapo B and Coronary Heart Disease	nan	COMPLETED
Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.	nan	UNKNOWN
Study of the Effect of Innate on the Inflammatory Response to Endotoxin	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a APOL1 binder may also engage these)

Protein	Name	Similarity
Q9BPW4	—	1.000	Q9BPW4 →
Q9BQE5	—	0.997	Q9BQE5 →
O95236	—	0.994	O95236 →
Q9BWW8	—	0.992	Q9BWW8 →
Q9BWW9	—	0.985	Q9BWW9 →
Q6AYC2	—	0.981	Q6AYC2 →
Q9DCE9	—	0.977	Q9DCE9 →
P05012	—	0.976	P05012 →
P01575	—	0.975	P01575 →
Q60766	—	0.975	Q60766 →
A0A140LIF8	—	0.975	A0A140LIF8 →
P70499	—	0.974	P70499 →
Q9SYZ8	—	0.973	Q9SYZ8 →
P01574	—	0.973	P01574 →
Q8CCN1	—	0.972	Q8CCN1 →
P01577	—	0.972	P01577 →
Q6XZW6	—	0.971	Q6XZW6 →
Q9JI58	—	0.971	Q9JI58 →
Q8CB12	—	0.971	Q8CB12 →
Q9N2J0	—	0.971	Q9N2J0 →
P18893	—	0.971	P18893 →
P01578	—	0.971	P01578 →
P01576	—	0.970	P01576 →
Q86W25	—	0.970	Q86W25 →
Q9P0W0	—	0.970	Q9P0W0 →
Q80ZF2	—	0.970	Q80ZF2 →
O77812	—	0.970	O77812 →
A0A0G2K7V7	—	0.969	A0A0G2K7V7 →
Q8TCY9	—	0.969	Q8TCY9 →
Q5RFJ8	—	0.969	Q5RFJ8 →