Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOL1 | O14791 | 18/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22747543 | 0.93 | APOL1 (1.00) | APOL1 | |
| SCHEMBL22160301 | 0.93 | APOL1 (1.00) | APOL1 | |
| SCHEMBL22160157 | 0.93 | APOL1 (1.00) | APOL1 | |
| SCHEMBL22160153 | 0.91 | APOL1 (0.71) | APOL1 | |
| SCHEMBL22159647 | 0.90 | APOL1 (0.88) | APOL1 | |
| SCHEMBL22160127 | 0.88 | APOL1 (0.84) | APOL1 | |
| SCHEMBL22161154 | 0.88 | APOL1 (1.00) | APOL1 | |
| SCHEMBL22161047 | 0.88 | APOL1 (1.00) | APOL1 | |
| SCHEMBL24907189 | 0.87 | APOL1 (0.89) | APOL1 | |
| SCHEMBL22160154 | 0.87 | APOL1 (0.89) | APOL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020131807-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-06-25 | — | — | WO | disclosed |