⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14688334 | 0.73 | KMT2A (0.37) | — | |
| SCHEMBL15831730 | 0.71 | CDK8 (0.33) | — | |
| SCHEMBL22164238 | 0.69 | LMNA (0.31) | — | |
| SCHEMBL21847663 | 0.66 | JAK2 (0.32) | — | |
| SCHEMBL22164240 | 0.66 | — | — | |
| SCHEMBL12982738 | 0.63 | HPGD (0.39) | — | |
| SCHEMBL8372142 | 0.62 | CYP19A1 (0.38) | — | |
| SCHEMBL930682 | 0.61 | — | — | |
| SCHEMBL12270026 | 0.60 | — | — | |
| SCHEMBL27262221 | 0.60 | MAPT (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230069963-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2023-03-09 | — | — | US | disclosed |
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |
| WO-2020138015-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | 大正製薬株式会社 | 2020-07-02 | — | — | WO | disclosed |