Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 8/20 | 0.69 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | OTUD7B | Q6GQQ9 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21023848 | 0.83 | CREBBP (0.69) | CREBBPPIK3CA | |
| SCHEMBL19657527 | 0.82 | CREBBP (1.00) | CREBBPPIK3CA | |
| SCHEMBL19657625 | 0.74 | CREBBP (0.73) | CREBBPPIK3CA | |
| SCHEMBL21024124 | 0.72 | CREBBP (0.82) | CREBBPPIK3CA | |
| SCHEMBL21024153 | 0.71 | CREBBP (0.71) | CREBBP | |
| SCHEMBL24258500 | 0.70 | CARM1 (0.38) | CREBBPPIK3CA | |
| SCHEMBL19657518 | 0.66 | CREBBP (1.00) | CREBBPPIK3CA | |
| SCHEMBL19657431 | 0.64 | CREBBP (1.00) | CREBBPPIK3CA | |
| SCHEMBL20133062 | 0.61 | CREBBP (0.48) | CREBBPOTUD7BABL1USP30MAP4K1 | |
| SCHEMBL29474164 | 0.60 | CREBBP (0.42) | CREBBPOTUD7BABL1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10696655-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2020-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10696655-B2 | Therapeutic compounds and uses thereof | EP300, HDAC1, HDAC11 | CREBBP 6/4885PIK3CA 2634/4885OTUD7B 4566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.