Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21736669 | 0.85 | KLKB1 (0.56) | KLKB1HSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL21736897 | 0.84 | KLKB1 (0.56) | KLKB1HSD17B10ALDH1A1CYP2D6HPGD | |
| SCHEMBL23830229 | 0.81 | KLKB1 (0.52) | KLKB1HSD17B10ALDH1A1CYP2D6HPGD | |
| Trifluoroacetic Acid SCHEMBL23830228 | 0.80 | KLKB1 (0.52) | KLKB1HSD17B10ALDH1A1CYP2D6HPGD | |
| Trifluoroacetic Acid SCHEMBL29906622 | 0.80 | KLKB1 (0.52) | KLKB1HSD17B10ALDH1A1CYP2D6HPGD | |
| SCHEMBL23768898 | 0.78 | KLKB1 (0.49) | KLKB1HSD17B10ALDH1A1CYP2D6HPGD | |
| SCHEMBL21736930 | 0.73 | KLKB1 (1.00) | KLKB1 | |
| SCHEMBL31741466 | 0.73 | KLKB1 (1.00) | KLKB1 | |
| SCHEMBL23843178 | 0.73 | KLKB1 (0.72) | KLKB1BTK | |
| SCHEMBL23843221 | 0.70 | KLKB1 (0.43) | KLKB1HSD17B10ALDH1A1CYP2D6HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10695334-B2 | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10695334-B2 | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | KLKB1, KLK1, KLK5 | KLKB1 1/4885HSD17B10 752/4885ALDH1A1 1415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.