Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.32 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17532291 | 1.00 | S1PR1 (0.36) | S1PR1S1PR4S1PR3S1PR5ENPP2 | |
| SCHEMBL17468520 | 0.95 | MAPK14 (0.35) | S1PR1S1PR4S1PR3S1PR5ENPP2 | |
| SCHEMBL22167389 | 0.95 | MAPK14 (0.35) | S1PR1S1PR4S1PR3S1PR5ENPP2 | |
| SCHEMBL17532290 | 0.95 | PYGL (0.33) | S1PR1S1PR5MAPK14MAPK11PYGL | |
| SCHEMBL22167228 | 0.94 | S1PR4 (0.35) | S1PR1S1PR4S1PR3S1PR5MAPK14 | |
| SCHEMBL17532289 | 0.94 | S1PR4 (0.35) | S1PR1S1PR4S1PR3S1PR5MAPK14 | |
| SCHEMBL17532298 | 0.94 | PYGL (0.33) | MAPK14MAPK11PYGLDDR1DDR2 | |
| SCHEMBL22167262 | 0.94 | S1PR1 (0.36) | S1PR1S1PR4S1PR3S1PR5ENPP2 | |
| SCHEMBL17532354 | 0.94 | S1PR1 (0.36) | S1PR1S1PR4S1PR3S1PR5ENPP2 | |
| SCHEMBL17492911 | 0.94 | S1PR4 (0.36) | S1PR1S1PR4S1PR3S1PR5MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172199-B1 | PYRIMIDINE DERIVATIVES AS GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-07-01 | — | — | EP | disclosed |