Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.51 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14134918 | 0.89 | POLB (0.54) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL28419749 | 0.84 | NPSR1 (0.61) | LMNAMAPTALDH1A1POLBRAB9A | |
| SCHEMBL5047364 | 0.83 | NPSR1 (0.65) | MEN1KMT2ALMNAHTTMAPT | |
| SCHEMBL19669104 | 0.83 | KMT2A (0.60) | MEN1KMT2ALMNAALDH1A1POLB | |
| SCHEMBL2742148 | 0.83 | ALDH1A1 (0.57) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL9517534 | 0.82 | MAPT (0.51) | MEN1KMT2ALMNAHTTMAPT | |
| SCHEMBL22081028 | 0.81 | GAA (0.62) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL22081030 | 0.81 | POLB (0.48) | MEN1KMT2ALMNAALDH1A1POLB | |
| SCHEMBL14134842 | 0.81 | MEN1 (0.59) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL6362321 | 0.81 | CNR2 (0.48) | LMNAALDH1A1POLBSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220506-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3Kdelta inhibitors | BEIGENE, LTD. (KY) | 2022-01-11 | — | — | US | disclosed |
| US-20200207774-A1 | IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3KDELTA INHIBITORS | BEONE MEDICINES I GMBH (CH) | 2020-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200207774-A1 | IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3KDELTA INHIBITORS | PIK3CD, PIK3R5, PIK3CA | MEN1 4245/4885KMT2A 1761/4885LMNA 3912/4885 |
| US-11220506-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3Kdelta inhibitors | PIK3CD, PIK3R5, PIK3CA | MEN1 4245/4885KMT2A 1761/4885LMNA 3912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.