Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 4/20 | 0.54 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KIF5B | P33176 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27112175 | 0.88 | KIT (0.52) | KITENPP1MEN1KMT2AMAPK1 | |
| SCHEMBL22164766 | 0.85 | KIT (0.57) | KITENPP1MEN1KMT2AMAPK1 | |
| SCHEMBL22300110 | 0.83 | KIT (0.55) | KITENPP1MEN1KMT2AMAPK1 | |
| SCHEMBL22164657 | 0.83 | KIT (0.57) | KITENPP1MEN1KMT2AMAPK1 | |
| SCHEMBL22300111 | 0.82 | KIT (0.56) | KITENPP1MEN1KMT2AMAPK1 | |
| SCHEMBL6180664 | 0.81 | KIT (0.61) | KITENPP1EGFRRETKDR | |
| SCHEMBL22165149 | 0.80 | KIT (0.52) | KITENPP1MEN1KMT2AMAPK1 | |
| SCHEMBL22300265 | 0.80 | EGFR (0.71) | EGFRCLK1ABCG2RETKDR | |
| Hydrochloric Acid SCHEMBL6180673 | 0.80 | EGFR (0.61) | KITENPP1EGFRRETKDR | |
| SCHEMBL22299722 | 0.79 | HTT (0.74) | MEN1KMT2AMAPK1STAT3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020140001-A1 | QUINAZOLINE DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | RIBOSCIENCE LLC (US) | 2020-07-02 | — | — | WO | disclosed |