Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Daunorubicin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A known ✓ | P11388 | 5/20 | 0.99 |
| ▸ | MEN1 | O00255 | 10/20 | 1.00 |
| ▸ | THRB | P10828 | 10/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 10/20 | 1.00 |
| ▸ | BLM | P54132 | 9/20 | 1.00 |
| ▸ | RECQL | P46063 | 8/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | BRCA1 | P38398 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 6/20 | 1.00 |
| ▸ | USP2 | O75604 | 5/20 | 1.00 |
| ▸ | S100A4 | P26447 | 5/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | PAX8 | Q06710 | 3/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 1.00 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Daunorubicin SCHEMBL31326687 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Daunorubicin SCHEMBL142541 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Daunorubicin SCHEMBL31725676 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Daunorubicin SCHEMBL4445 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Daunorubicin SCHEMBL4444 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Daunorubicin SCHEMBL122984 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Daunorubicin SCHEMBL4659664 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Daunorubicin SCHEMBL20185623 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Daunorubicin SCHEMBL20204237 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Daunorubicin SCHEMBL29462666 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117769594-A | Methods and compositions for remote control of T cell therapies by heat targeting | 乔治亚技术研究公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-117062625-A | Combination therapy with FOR FOR46 FOR cancer | 福蒂斯治疗公司 | 2023-11-14 | — | — | CN | disclosed |
| US-20110178182-A1 | ENRICHED NANOSTRUCTURE COMPOSITION | DO-COOP TECHNOLOGIES LTD. | 2011-07-21 | — | — | US | disclosed |
| EP-2190562-A2 | ENRICHED NANOSTRUCTURE COMPOSITION | Do-Coop Technologies Ltd (IL) | 2010-06-02 | — | — | EP | disclosed |
| US-20100086929-A1 | DETECTION OF ANALYTES | DO-COOP TECHNOLOGIES LTD. (IL) | 2010-04-08 | — | — | US | disclosed |
| US-20100041103-A1 | COMPOSITION AND METHOD FOR ENHANCING CELL GROWTH AND CELL FUSION | DO-COOP TECHNOLOGIES LTD. | 2010-02-18 | — | — | US | disclosed |
| EP-2121943-A2 | COMPOSITION AND METHOD FOR ENHANCING CELL GROWTH AND CELL FUSION | Do-Coop Technologies Ltd (IL) | 2009-11-25 | — | — | EP | disclosed |
| EP-2122350-A2 | DETECTION OF ANALYTES | Do-Coop Technologies Ltd (IL) | 2009-11-25 | — | — | EP | disclosed |
| US-20090253613-A1 | Solid-Fluid Composition | DO-COOP TECHNOLOGIES LTD. (IL) | 2009-10-08 | — | — | US | disclosed |
| US-20090081305-A1 | Compositions and Methods for Enhancing In-Vivo Uptake of Pharmaceutical Agents | DO-COOP TECHNOLOGIES LTD. | 2009-03-26 | — | — | US | disclosed |
| WO-2009024976-A2 | ENRICHED NANOSTRUCTURE COMPOSITION | DO-COOP TECHNOLOGIES LTD. (IL) | 2009-02-26 | — | — | WO | disclosed |
| US-20090004296-A1 | Antiseptic Compositions and Methods of Using Same | DO-COOP TECHNOLOGIES LTD. | 2009-01-01 | — | — | US | disclosed |
| EP-1981987-A2 | COMPOSITIONS AND METHODS FOR ENHANCING IN-VIVO UPTAKE OF PHARMACEUTICAL AGENTS | Do-Coop Technologies Ltd (IL) | 2008-10-22 | — | — | EP | disclosed |
| EP-1981989-A2 | SOLID-FLUID COMPOSITION | Do-Coop Technologies Ltd (IL) | 2008-10-22 | — | — | EP | disclosed |
| WO-2008081456-A2 | COMPOSITION AND METHOD FOR ENHANCING CELL GROWTH AND CELL FUSION | DO-COOP TECHNOLOGIES LTD. (IL) | 2008-07-10 | — | — | WO | disclosed |
| WO-2008081455-A2 | DETECTION OF ANALYTES | DO-COOP TECHNOLOGIES LTD. (IL) | 2008-07-10 | — | — | WO | disclosed |
| WO-2007077561-A2 | COMPOSITIONS AND METHODS FOR ENHANCING IN-VIVO UPTAKE OF PHARMACEUTICAL AGENTS | DO-COOP TECHNOLOGIES LTD. (IL) | 2007-07-12 | — | — | WO | disclosed |
| WO-2007077563-A2 | SOLID-FLUID COMPOSITION | DO-COOP TECHNOLOGIES LTD. (IL) | 2007-07-12 | — | — | WO | disclosed |
| EP-1536791-A1 | SUSTAINED-RELEASE TABLET COMPRISING REBOXETINE | Pharmacia Corporation (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004010998-A1 | SUSTAINED-RELEASE TABLET COMPRISING REBOXETINE | PHARMACIA CORPORATION (US) | 2004-02-05 | — | — | WO | disclosed |