⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2217425 | 1.00 | — | — | |
| SCHEMBL1844869 | 0.74 | — | — | |
| SCHEMBL1844864 | 0.74 | — | — | |
| SCHEMBL10594347 | 0.74 | — | — | |
| SCHEMBL11132436 | 0.72 | — | — | |
| SCHEMBL925412 | 0.72 | — | — | |
| SCHEMBL15374310 | 0.71 | — | — | |
| SCHEMBL1255904 | 0.71 | LMNA (0.33) | — | |
| SCHEMBL2170002 | 0.71 | — | — | |
| SCHEMBL15374309 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130345432-A1 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC. (US) | 2013-12-26 | — | — | US | disclosed |
| US-8501954-B2 | Asymmetric process for making substituted 2-amino-thiazolones | AMGEN INC. (US) | 2013-08-06 | — | — | US | disclosed |
| EP-2321290-B1 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC (US) | 2012-06-20 | — | — | EP | disclosed |
| US-20110178307-A1 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC. (US) | 2011-07-21 | — | — | US | disclosed |
| EP-1753736-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC (US) | 2008-12-17 | — | — | EP | disclosed |